San Francisco is the most expensive city in California. In the ranking of the most expensive cities in the US, San Francisco is ranked second in 2022. The average rental price for a one-bedroom apartment is $3,000 per month (July 2022). Average apartment rental prices in San Francisco’s most expensive neighborhoods range from $3,000 to $3,700 per month. Mission Bay is the most expensive neighborhood in San Francisco. The average price for renting a one-bedroom apartment in Mission Bay is $3,680 per month (July 2022). The top 5 most expensive neighborhoods in San Francisco also include South Beach ($3,570 per month), SOMA ($3,410 per month), Russian Hill ($3,345 per month) and Hayes Valley ($3,330 per month).